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Rhythm – the most important for healthy nutrition

Scientists Institute for Biological Studies (Salk Institute for Biological Studies), Salk, U.S., found that the work of the liver – the main body, cleanse the body of metabolic products depends to a large extent on the date of the food than on the circadian clock of the individual . In other words, the liver is actively involved in the work (and at the level of thousands of genes, say the authors) Upon receipt of food in the body. However, the mechanism has been verified in experiments on mice, reported Infox.

To understand how the rhythm of food affects the liver, co-author Christopher Vollmers (Christopher Vollmers) selected two groups of mice – one with a normal circadian rhythm, the other Biased. All the experimental feeding on the same rigid schedule, while controlling the work of individual genes in the genome. The authors found that when the feeding regime that included 16-hour fasting in both groups was set the same rhythm of the functioning of most of the genes responsible for metabolism. Conversely, during prolonged fasting in a group of rodents with normal biological clock work metabolic genes was maintained only at a minimal level.

«Transcription of genes in this case, the plateau, running, as an hourglass – a weakly and strongly in a certain amount, at a minimum, – said Vollmers. – In the real world we often are not able to eat in the same time, it is essential for the activation of metabolic genes, especially those that are responsible for fat and carbohydrate exchange. ” “If indeed it is the ingestion of food influences the activity of many genes, the correct schedule of food can quickly and effectively adjust the metabolism,” – said study author Satchidananda Panda (Satchidananda Panda), PhD, associate professor and fellow of the Institute Biolaboratory.

The new data help explain why people who have no clear timetable for power, are particularly prone to metabolic syndrome, diabetes, cholesterol metabolism and obesity. “We believe that it is constantly changing nature of power within a week: in the workplace people are fed in one way, and during the weekend by another”, – says Panda.

In mammals, the basis of circadian rhythms laid down the rhythm of the brain and auxiliary sources localized in peripheral parts of the body. The clock in the brain focused on changing light during the day and night, and determine the life of the animal including the periodicity of sleep and wakefulness, as well as the rhythm of food. At the periphery of the nervous system so sensitive to external conditions is not observed, but the time factor food plays a significant role in the first.

«rhythmic component, located in the liver, contributes significantly to the organism to adapt to the daily regime of eating, temporarily adjusting the activity of thousands of genes, regulatory and metabolism, and physiology – says Panda. – This regulation is very important, as inconsistency normal circadian clock power supply leads the organism to various metabolic dysfunction and disease ».

« Our study seriously alter the existing opinion circadian rhythm, – says Panda. – circadian clock, it turns out, are not the sole driver of the rhythms of gene functions. Phase and amplitude of rhythmic gene function in liver determined by periods of food and hunger – the more precise they are, the harmonious vibrations are gene activity ».

As a companion experiment Panda himself stopped is between 20.00 and 8.00, and now notes significant improvement in their own health. “I even lost weight, although I spent the day eating whatever I want” – shares his discoveries of the scientist.